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 HBV mutation literature information.


  C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties.
 PMID: 27006468       2016       Oncotarget
Abstract: Stable overexpression of the naturally occurring HBx-DeltaC mutants, HBx-Delta14 or HBx-Delta35, in HCC cells Huh7 and immortalized normal liver cells MIHA resulted in a significant increase in the cells ability to self-renew, resist chemotherapy and targeted therapy, migrate and induce angiogenesis.
Introduction: The stable overexpression of HBx-Delta14 or HBx-Delta35 in HCC cell line Huh7 and immortalized normal liver cell line MIHA resulted in a significant increase of the cells ability to self-renew, resist 5-fluorouracil and sorafenib, migrate and induce capillary tube formation in endothelial cells.
Figure: (B) U



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